Nolvadex is the brand name of the drug called Tamoxifen Citrate and the brand is currently owned by AstraZeneca. But this product can be sold as numerous other brand names by numerous other pharmaceutical companies for much lower prices.
The compound is a Selective Estrogen Receptor Modulator (SERM) that is coming in the form of oral pills.
This is a very popular product that is widely used both in medical settings and in the bodybuilding world.
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Nolvadex in Medical Settings
Tamoxifen (Nolvadex) is FDA approved and is currently on the list of the World Health Organization (WHO) of essential medicines. This means that the compound is very effective and remains safe when used properly.
In medical settings, Nolvadex is used for the treatment or prevention of breast cancer in women and is used for the treatment of breast cancer or gynecomastia in men. Plus to that, Tamoxifen can be used for treating female infertility because there are studies proving that the compound is doubling the chances of pregnancy.
There are many other uses of Tamoxifen Citrate (Nolvadex) in medical settings too.
Nolvadex in Bodybuilding
The product Nolvadex in bodybuilding is very widely used. Because it is extremely helpful either for treating or preventing gynecomastia or for Post Cycle Therapy (PCT) plans.
However, Tamoxifen is not very effective for other estrogen related issues except for gynecomastia.
- That’s why Aromatase Inhibitors (AIs) are preferred for gynecomastia prevention during the use of aromatized anabolic steroids.
- Tamoxifen is preferred for PCT regimens in order to help bodybuilders restart their natural production of testosterone.
SERMs vs AIs
As mentioned, Nolvadex is a SERM (exactly as Clomid – Clomiphene Citrate) and is preferred for PCT plans. But for controlling estrogen levels and therefore preventing gynecomastia and other estrogenic issues, AIs (Aromatase Inhibitors) are more favored.
Both SERMs and AIs are known to deal with estrogen related issues (therefore are anti-estrogens).
However, AIs are known to bind to aromatase enzymes and therefore prevent aromatization. That’s why they lower the amount of estrogen in the body.
On the other hand, SERMs are binding to estrogen receptors and only to some specific estrogen receptors in the body (that’s why are called selective). Whilst they prevent the action of estrogen in some areas of the body, they are boosting the estrogen activity in other areas of the body.
How Does Nolvadex Work?
For example, it blocks estrogen action in breast tissues. That’s why they are helpful for preventing and treating breast cancer or gynecomastia.
Other than that, it also blocks the estrogen from reaching the pituitary gland. That’s why is helpful for producing testosterone naturally.
But it increases estrogen activity in ovaries. That’s why they are helpful for infertility issues.
That’s why, if you’re wondering what does Nolvadex do – you got the answer.
In short, it blocks the estrogen activity in some specific areas of the body and boosts estrogen activity in other areas of the body.
- That’s why Nolvadex is lowering the chances of gynecomastia or estrogen receptor positive breast cancer and is helpful to boost the natural production of testosterone. It blocks estrogen from reaching the pituitary gland and breast tissues.
That’s why is so popular for bodybuilders and athletes running anabolic steroids who are likely to increase estrogen. This is a hormone that may cause gynecomastia from the use of aromatized steroids. Also, using steroids they are going to suppress the natural production of testosterone. All steroids suppress the production of testosterone.
Nolvadex Side Effects
Keep in mind that because of what Nolvadex does, you are likely to get side effects too. Usually, those men who run it properly do not get side effects. But this SERM is still not completely side effects free.
Tamoxifen is likely to cause nausea, vomiting, headaches as well as other serious side effects, but they usually occur only if you’re using the compound in way too high doses.
If you run Nolvadex for PCT then it usually starts at 40 mg per day for the first and second week. Then the dosage is lowered to 10-20 mg per day for the third and fourth week.
In case you’re using Nolvadex for gynecomastia then the dosages are highly dependent on various factors such as the dosage of steroids, whether you want to prevent gynecomastia or treat it etc. Generally, dosages are between 20 and 80 mg per day.
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