Anastrozole VS Exemestane

Anastrozole vs Exemestane is a pretty popular topic taken into consideration that these are 2 extremely popular and widely used Aromatase Inhibitors (AIs), both coming in the form of oral pills and both offering similar results and even similar side effects.

  • PS: Another notable Aromatase Inhibitor (AI) is Letrozole with the brand name Femara.

Anastrozole is the chemical name in the brand Arimidex, yet it can be found as many other trade names too. The same applies to Exemestane which is the active substance in the most famous brand Aromasin. But there are many other trade names for it as well.

So, when you talk about Anastrozole vs Exemestane, the brands would be Arimidex vs Aromasin (many people might be more familiar with the brand of a compound instead of the chemical name).

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Anastrozole vs Exemestane Similarities

As it was earlier mentioned, both Anastrozole vs Exemestane (Arimidex vs Aromasin) come in form of oral pills. They are both Aromatase Inhibitors (AIs). Therefore they are both doing an amazing job in lowering total estrogen levels in the body as soon as they are administered.

They are even working similarly. Obviously offering similar results, similar side effects, and are used for similar needs.

Anastrozole and Exemestane are both binding to aromatase enzymes and therefore, preventing aromatization into estrogen, that’s how they lower estrogen levels in the body.

This is the reason why they are both used for similar needs – for whenever is required to lower estrogen levels.

For example, for medical purposes, they are used to lower estrogen levels in female patients suffering from breast cancer. Cancer that requires estrogen to form and grow. When estrogen is suppressed thanks to the use of either of these drugs, cancer cannot grow and it may be treated.

But in bodybuilding purposes, they are used either for PCT protocols (to boost testosterone levels) but that’s rare. Mostly Anastrozole and Exemestane are used for controlling estrogen during the use of aromatized steroids.


Aromasin vs Arimidex Uses

When users go for a steroid cycle, during the cycle – they are likely to get a spike in estrogen. Therefore, estrogen-related issues are possible.

When Arimidex or Aromasin are used – they control the estrogen.

Both are likely to offer similar side effects, taking into consideration that the most common side effects of these compounds are related to low estrogen levels (which is a sign that dosages are too high and too much estrogen is suppressed).

Some of the side effects can include:

  • Dry and painful joints
  • Fatigue and nausea
  • Low energy levels
  • Low mood and depression
  • No sex drive and libido
  • And there are others too

In the end, Anastrozole vs Exemestane are very similar compounds, yet there are still differences.

Anastrozole vs Exemestane Differences

Despite being so similar, they are still different.

  • The major difference between Arimidex and Aromasin (Anastrozole vs Exemestane) is that Arimidex (Anastrozole) is a nonsteroidal aromatase inhibitor unlike Aromasin (Exemestane) which is a steroidal AI (suicidal).

This means that as soon as Exemestane binds to aromatase enzymes, it permanently disables them. Unlike Anastrozole that only binds to the aromatase enzymes for as long as it is in the body. With this being said, Exemestane is better than Anastrozole at not allowing estrogen to rebound when you stop the administration.

Another benefit of Exemestane is that it lowers SHBG and whilst it won’t have a negative effect on gains like Anastrozole might – it may even be helpful for your gains. Due to this, it is also a better option for PCT plans.

However, Anastrozole has its own advantages over Exemestane.

For example, the first one is the fact that Arimidex is way cheaper than Exemestane. Many bodybuilders go for Arimidex instead of Aromasin mostly because they can save up a lot. In medical settings, Arimidex is the first-line treatment of breast cancer, but Aromasin is the second-line treatment.


Another thing that can be mentioned – is more likely you are going to get side effects from Exemestane rather than Anastrozole, is because Anastrozole is easier to control and adjust dosages. Mainly is because Exemestane permanently disables aromatization, unlike Anastrozole. Therefore it requires a while until estrogen levels come back to normal in case of emergency.

In Conclusion

  • Dosages of Anastrozole for bodybuilding: from 0.5 mg every other day up to 1 mg per day
  • Dosages of Exemestane for bodybuilding: from 12.5 mg every other day up to 25 mg per day

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In the end, you can buy the best quality compounds from Regardless if talking about Anastrozole or Exemestane. In addition to that – you might save a lot of money too, as we have the lowest prices.

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